Micronutrients and Infection with COVID-19: A Critical Mini-Review

Document Type : Mini Review


1 Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 Faculty of Science, Liverpool Hope University, Hope Park Campus, Taggart Avenue, Liverpool, L16 9JD, United Kingdom

3 Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been the cause of a global pandemic. Given the impact of nutritional status upon immune function, it is crucial to understand the relationship between micronutrient intake and severity of the disease. This mini-review aimed to summarize the known associations between specific micronutrients (vitamin A, D, E, C and zinc, selenium and magnesium) and the health of coronavirus-infected patients. Low serum levels of these micronutrients are associated with the incidence and severity of SARS-CoV-2. However, further studies are needed to evaluate the outcomes of supplementation with these nutrients.



The coronavirus disease 2019 (COVID-19) has been the cause of a global pandemic. From December 2019, strict restrictions and quarantine have been imposed around the world, but prevalence of the disease and mortality remained high [1]. Patients with COVID-19 exhibit varying clinical manifestations, ranging from asymptomatic or mild symptoms, to serious complications which may, potentially lead to death [2]. Advanced age, obesity, diabetes mellitus, existing respiratory system disease, hypertension, and cardiovascular disease are associated with a poor prognosis [3].

Epidemiological studies are in progress to investigate the relationship between dietary micronutrients, nutrient, foods, or food patterns and COVID-19 [4, 5]. In this mini-review, we have summarized the potential associations or effects of micronutrients and COVID-19 as deficiencies have been shown to reduce immune function, and therefore potentially increase susceptibility to COVID-19 and subsequent secondary infection [6]. Vitamins such as A, D, E and C and minerals like zinc, selenium and magnesium have received particular attention in previous studies. Therefore
we focused on these micronutrients in this mini-
review [7].

Vitamin A

Vitamin A is present in two forms in the diet: carotenoids as a precursor form predominantly found in vegetables such as carrots, squashes, pumpkin, spinach and broccoli; or an active form called retinol which is consumed through animal sources, such as egg, turkey and fortified foods [8]. Vitamin A has been proposed to enhance immune response against influenza and measles viruses [9]. Vitamin A deficiency commonly accompanies protein malnutrition; therefore, both protein and vitamin A supplementation are recommended to treat these deficiencies. Cough, fever and greater total respiratory resistance were reported to be associated with vitamin A deficiency in patients who were infected with respiratory tract diseases with manifestations similar to COVID-19 [10]. 

Vitamin D

The fat-soluble vitamin D, is primarily synthesized in the skin during exposure to UV light,  it is then hydroxylated by liver and kidneys to produce the active form of vitamin D, calcitriol (1, 25-dihydroxy-vitamin D3) [11]. Beyond its effects on musculoskeletal, cardiovascular, endocrine and nervous systems, vitamin D has been shown to confer immunoprotection [12]. Vitamin D is an anti-inflammatory and anti-microbial regulator, which assists with the maintenance of the immune system by suppressing the transcription of inflammatory cytokines [13]. Previous studies have shown that cytokine release syndrome (known as cytokine storm) is an important cause of death among patients with COVID-19 [14]. The association between vitamin D deficiency, cytokine storm, and high mortality in COVID-19 infected patients have been highlighted by several studies [15, 16]. For example, a cross-sectional study investigating relationship between COVID-19 and vitamin D status in 37 Asia pacific countries has shown a negative association between mean vitamin D levels and rate of morbidity; however, the association between vitamin D levels and mortality was not significant [17]. Furthermore, a study of 137 coronavirus-infected patients with vitamin D deficiency, revealed an inverse association between serum vitamin D levels and in-hospital mortality [18]. A systematic review study suggests that vitamin D supplementation has protective effects against overall acute respiratory tract infection and that vitamin D supplementation was most beneficial in those patients who were vitamin D deficient [19]. In summary, coronavirus-infected patients with vitamin D deficiency are more likely to get worse than patients without vitamin D deficiency. More investigations on advantages and disadvantages of vitamin D supplementation are needed.

Vitamin C

Vitamin C is a well-known antioxidant and immune-protective nutrient which can be obtained mostly from plant sources like citrus fruits, tomatoes and peppers [20]. Previous studies suggest that vitamin C can improve immunity through its effective role on T-cells maturation [21]. Some evidence indicates that vitamin C might also have antiviral effects [22, 23] and can help the body against respiratory infections [24]. For example, an observational investigation suggested that food source intake of vitamin C may reduce the risk of upper respiratory tract infections among women, and a combination of vitamin C and vitamin E supplementation may lower the risk of upper respiratory tract infections among men [25]. These results led researchers to consider the impact of vitamin C deficiency and intake upon the prevalence and progression of COVID-19. Physiological stress like infection may lead to a decrease in serum vitamin C levels as it occurs in coronavirus-infected patients [26]. Based on previous studies, the most protective effects of vitamin C administration were observed in patients with decreased levels of vitamin C [27]. Further evidence also suggests that high-doses of vitamin C (100 mg/kg/day) in COVID-19 infected patients with vitamin C deficiency may be beneficial [28]. A review investigating COVID-19 and vitamin C supplementation, could not confirm a significant protective effect of vitamin C against the disease, but suggests that high dose administration of vitamin C in those who are critically ill, especially those with decreased levels of vitamin C, may be beneficial [29]. However, a clinical trial on 30 patients with COVID-19 did not find any significant difference in a case group treated by high doses of vitamin C (6 g/day) and the control group [30]. Another investigation regarding patients with severe COVID-19 infection in China failed to demonstrate any reduction in 28-day mortality rates after high-dose vitamin C administration; however, a potential positive effect on oxygenation was highlighted [31]. Given the conflicting findings in the literature, further clinical trials are required to clarify the effects of high-dose vitamin C administration in patients infected with COVID-19.

Vitamin E

Vitamin E available as tocopherols and tocotrienols is a fat-soluble vitamin, which is naturally present in foods such as vegetable oils and nuts [32]. Vitamin E has antioxidant capabilities, which rely on other cellular antioxidant components such as vitamin C [33]. The antioxidant potential of vitamin E protects polyunsaturated fatty acids (PUFAs) against free radicals. Vitamin E supplementation enhances human immunity by increasing lymphocyte proliferation and interleukin 2 (IL-2) production, and reducing interleukin 6 (IL-6) production [34]. Several animal and human studies have demonstrated inverse associations between respiratory disorders (like pneumonia, influenza, and asthma) and vitamin E status due to its immune-regulatory features [35]. Despite this, the efficacy of vitamin E supplementation regarding respiratory tract infections is not fully known. One study designed to investigate the effect of 200 IU/day vitamin E supplementation in an elderly population did not find any significant relationship; however,  a lower incidence of the common cold among those who received the supplementation was revealed [36]. A previous cohort study indicated an inverse relationship between dietary intake of vitamin E among women and incidence of upper respiratory tract infection [37]. However, other evidence has demonstrated harmful effects of vitamin E supplementation in elderly individuals with respiratory tract problems [38]. More recently, a randomized control trial has commenced to evaluate the effect of daily intake of multivitamins, including vitamins E, A, D, C and B, upon patients with COVID-19 [39]. More robust studies are needed to fully elucidate the relationship between vitamin E status and the progression of COVI-19.


Zinc is an essential trace mineral, which plays a crucial role in several activities in the body including gene expression, protein synthesis, enzymatic reactions and immune function. Zinc is widely found in plant and animal food sources. It can also be obtained by supplementation [40]. Although severe zinc deficiency is not common, mild zinc deficiency is prevalent especially among vegetarians  and elderly individuals [41]. An observational study showed that low serum zinc levels in elderly might make them susceptible to pneumonia. Also, zinc deficient individuals may respond better to supplementation [42] and previous studies have shown that zinc deficiency leads to immune dysfunction that may worsen inflammation or infection status [43]. Zinc is potentially an antiviral agent that plays role in influenza and COVID-19 inhibition [44, 45]. A meta-analysis has shown a positive effect of zinc supplementation for the treatment of the common cold [46]. Furthermore, an investigation on the efficacy of zinc treatment on 28 outpatients with COVID-19, demonstrated an improvement in all participants [47]. Moreover, another clinical study on serum zinc levels in 249 COVID-19 patients revealed a strong correlation between low serum zinc levels (


Selenium is a vital compound which has antioxidant and enzyme activities [50]. Selenium is necessary for maintaining the function of immune system [51]. Based on previous studies, individuals who were defincient in selenium were more prone to infections and inflammation and respond better to dietary selenium intake as well as supplementation [52]. Low levels of plasma selenium are associated with an elevated level of oxidative stress and higher susceptibility to viral infections [53, 54]. Due to important role of selenium in immune function, some studies have suggested a relationship between selenium status and coronavirus disease. An investigation in China, demonstrated a positive correlation between  patients who recovered from COVID-19 and selenium status [55]. This finding was also corroborated by a recent cross-sectional study in Germany, which highlighted a strong relationship between selenium deficiency and the mortality rate of patients infected with COVID-19 [56]. As few studies have examined the relationship between selenium status and COVID-19, more investigations are suggested in this regard.


Magnesium is an essential trace element, which is functionally related to vitamin D. Vitamin D activation, is dependent on magnesium, via regulating the blood transportation of vitamin D. Magnesium deficiency may lead to a reduction in calcitriol (active form of vitamin D) levels [57, 58]. Poor diet, chronic disease and stress are some causes of magnesium deficiency. Magnesium deficiency can result in inflammation and damaged immune function. It can also lead to an increase in oxidative stress [59, 60]. One study demonstrated a remarkable reduction in NK (natural killer) and CD8+ (cytotoxic) T cells (which are crucial for combating viral infections) in coronavirus-infected patients with magnesium deficiency; that may cause cytokine storm in the lungs and consequently worsen the progression of COVID-19 [61]. Magnesium supplementation (in the form of L-threonate) increases intracellular magnesium levels and help the NK and CD8+ T cells restoration [62]. A recent study on older patients infected with COVID-19, interestingly demonstrated a decrease in the oxygen and intensive care support requirement in patients who were treated by a combination of magnesium, vitamin D and vitamin B12 [63]. Since magnesium and vitamin D deficiency worsen the inflammation status, a previous study has suggested to consider magnesium and vitamin D co-supplementation as a helpful approach during COVID-19 pandemic [64]. Although the vital role of magnesium in health maintenance is well known, further studies are needed to ensure the effect of magnesium supplementation on COVID-19 patients.


Several studies have highlighted the negative effects of COVID-19 on numerous aspects of human life including health status. This review suggests that low serum levels of certain micronutrients may be associated with the incidence and severity of the disease. Consumption of rich sources of these nutrients may be helpful for preventing and treating patients infected with COVID-19 and may facilitate their recovery. Despite this, further studies are needed to evaluate the outcomes of supplementation with these nutrients.


Nothing to declare

Authors’ contributions

All authors contributed to this project and article equally. All authors read and approved the final version of the manuscript.

Funding source


Conflict of Interest

The authors declare that there is no potential conflict of interests in this review.

[1] Organization WH. Coronavirus disease ( COVID-19)‎. 2020
[2] Lai C-C, Shih T-P, Ko W-C, Tang H-J, Hsueh P-R. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. International journal of antimicrobial agents. 2020;55:105924
[3] Age C. Worldometer Available at: https://www. worldometers. info/coronavirus/coronavirus-age-sex-demographics. Accessed April. 2020;5
[4] Cintoni M, Rinninella E, Annetta MG, Mele MC. Nutritional management in hospital setting during SARS-CoV-2 pandemic: a real-life experience. European journal of clinical nutrition. 2020;74:846-7
[5] Caccialanza R, Laviano A, Lobascio F, Montagna E, Bruno R, Ludovisi S, et al. Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol. Nutrition. 2020;74:110835
[6] Gasmi A, Tippairote T, Mujawdiya PK, Peana M, Menzel A, Dadar M, et al. Micronutrients as immunomodulatory tools for COVID-19 management. Clinical Immunology. 2020:108545
[7] Detopoulou P, Demopoulos CA, Antonopoulou S. Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism. Nutrients. 2021;13:462
[8] Gilbert C. What is vitamin A and why do we need it? Community eye health. 2013;26:65
[9] Sudfeld CR, Navar AM, Halsey NA. Effectiveness of measles vaccination and vitamin A treatment. International journal of epidemiology. 2010;39:i48-i55
[10] de Andrade MIS, de Macêdo PFC, de Oliveira TLPS, da Silva Lima NM, da Costa Ribeiro I, Santos TM. Vitamin A and D deficiencies in the prognosis of respiratory tract infections: A systematic review with perspectives for COVID-19 and a critical analysis on supplementation.
[11] Linnebur SA, Vondracek SF, Vande Griend JP, Ruscin JM, McDermott MT. Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. The American Journal of Geriatric Pharmacotherapy. 2007;5:1-8https://doi.org/ 10. 1016/ j.amjopharm.2007.03.005.
[12] LoPiccolo MC, Lim HW. Vitamin D in health and disease. Photodermatology, photoimmunology & photomedicine. 2010;26:224-9
[13] Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016;96:365-40810.1152/physrev. 00014.2015.
[14] Moore JB, June CH. Cytokine release syndrome in severe COVID-19. Science. 2020;368:473-410.1126/science.abb8925.
[15] Ahmed F. A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection. Front Immunol. 2020;11:59045910.3389/ fimmu. 2020.590459.
[16] Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. The possible role of vitamin D in suppressing cytokine storm and associated mortality in COVID-19 patients. MedRxiv. 2020
[17] Yadav D, Birdi A, Tomo S, Charan J, Bhardwaj P, Sharma P. Association of Vitamin D Status with COVID-19 Infection and Mortality in the Asia Pacific region: A Cross-Sectional Study. Indian J Clin Biochem. 2021:1-610.1007/s12291-020-00950-1.
[18] Infante M, Buoso A, Pieri M, Lupisella S, Nuccetelli M, Bernardini S, et al. Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study. J Am Coll Nutr. 2021:1-1610.1080/07315724.2021.1877580.
[19] Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Bmj. 2017;356: i658310.1136/bmj.i6583.
[20] Chambial S, Dwivedi S, Shukla KK, John PJ, Sharma P. Vitamin C in disease prevention and cure: an overview. Indian J Clin Biochem. 2013;28:314-2810.1007/s12291-013-0375-3.
[21] Manning J, Mitchell B, Appadurai DA, Shakya A, Pierce LJ, Wang H, et al. Vitamin C promotes maturation of T-cells. Antioxid Redox Signal. 2013;19:2054-6710.1089/ars.2012.4988.
[22] Furuya A, Uozaki M, Yamasaki H, Arakawa T, Arita M, Koyama AH. Antiviral effects of ascorbic and dehydroascorbic acids in vitro. Int J Mol Med. 2008;22:541-5
[23] Colunga Biancatelli RML, Berrill M, Marik PE. The antiviral properties of vitamin C. Expert Rev Anti Infect Ther. 2020;18:99-10110.1080/14787210. 2020.1706483.
[24] Hemilä H. Vitamin C, respiratory infections and the immune system. Trends Immunol. 2003;24:579-8010.1016/j.it.2003.09.004.
[25] Fondell E, Bälter O, Rothman KJ, Bälter K. Dietary intake and supplement use of vitamins C and E and upper respiratory tract infection. J Am Coll Nutr. 2011;30:248-5810.1080/07315724.2011.10719967.
[26] Holford P, Carr AC, Jovic TH, Ali SR, Whitaker IS, Marik PE, et al. Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19. Nutrients. 2020;1210.3390/nu12123760.
[27] Patterson T, Isales CM, Fulzele S. Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection. Aging Dis. 2021;12:14-2610.14336/ad.2020.0918.
[28] Xing Y, Zhao B, Yin L, Guo M, Shi H, Zhu Z, et al. Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding. J Pharm Biomed Anal. 2021;196:11392710.1016/j.jpba.2021.113927.
[29] Hemilä H, de Man AME. Vitamin C and COVID-19. Front Med (Lausanne). 2020;7:55981110.3389/ fmed.2020.559811.
[30] JamaliMoghadamSiahkali S, Zarezade B, Koolaji S, SeyedAlinaghi S, Zendehdel A, Tabarestani M, et al. Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. Eur J Med Res. 2021;26:2010.1186/ s40001-021-00490-1.
[31] Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021;11:510.1186/ s13613-020-00792-3.
[32] Olza J, Aranceta-Bartrina J, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G, et al. Reported Dietary Intake and Food Sources of Zinc, Selenium, and Vitamins A, E and C in the Spanish Population: Findings from the ANIBES Study. Nutrients. 2017;910.3390/nu9070697.
[33] Chou CC, Sung YC, Davison G, Chen CY, Liao YH. Short-Term High-Dose Vitamin C and E Supplementation Attenuates Muscle Damage and Inflammatory Responses to Repeated Taekwondo Competitions: A Randomized Placebo-Controlled Trial. Int J Med Sci. 2018;15:1217-2610.7150/ ijms. 26340.
[34] Lee GY, Han SN. The Role of Vitamin E in Immunity. Nutrients. 2018;1010.3390/nu10111614.
[35] Lewis ED, Meydani SN, Wu D. Regulatory Role of Vitamin E in the Immune System and Inflammation. IUBMB life. 2019;71:487-94
[36] Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, et al. Vitamin E and Respiratory Tract Infections in Elderly Nursing Home ResidentsA Randomized Controlled Trial. JAMA. 2004;292:828-3610.1001/jama.292.7.828.
[37] Raposo SE, Fondell E, Ström P, Bälter O, Bonn SE, Nyrén O, et al. Intake of vitamin C, vitamin E, selenium, zinc and polyunsaturated fatty acids and upper respiratory tract infection-a prospective cohort study. Eur J Clin Nutr. 2017;71:450-710.1038/ejcn.2016.261.
[38] Hemilä H. Vitamin E supplementation and respiratory infections in older people. J Am Geriatr Soc. 2007;55:1311-3; author reply 3-410.1111/ j.1532-5415.2007.01263.x.
[39] Beigmohammadi MT, Bitarafan S, Hoseindokht A, Abdollahi A, Amoozadeh L, Mahmoodi Ali Abadi M, et al. Impact of vitamins A, B, C, D, and E supplementation on improvement and mortality rate in ICU patients with coronavirus-19: a structured summary of a study protocol for a randomized controlled trial. Trials. 2020;21:61410. 1186/s13063-020-04547-0.
[40] Haase H, Rink L. Multiple impacts of zinc on immune function. Metallomics. 2014;6:1175-8010. 1039/c3mt00353a.
[41] Allès B, Baudry J, Méjean C, Touvier M, Péneau S, Hercberg S, et al. Comparison of Sociodemographic and Nutritional Characteristics between Self-Reported Vegetarians, Vegans, and Meat-Eaters from the NutriNet-Santé Study. Nutrients. 2017;9:1023
[42] Barnett JB, Hamer DH, Meydani SN. Low zinc status: a new risk factor for pneumonia in the elderly? Nutrition reviews. 2010;68:30-7
[43] Gammoh NZ, Rink L. Zinc in Infection and Inflammation. Nutrients. 2017;9:624
[44] Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The Role of Zinc in Antiviral Immunity. Adv Nutr. 2019;10:696-71010.1093/advances/nmz013.
[45] te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010;6:e100117610.1371/journal.ppat.1001176.
[46] Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open. 2017;8:2054270417694291
[47] Finzi E, Harrington A. Zinc treatment of outpatient COVID-19: A retrospective review of 28 consecutive patients. J Med Virol. 202110.1002/ jmv.26812.
[48] Vogel-González M, Talló-Parra M, Herrera-Fernández V, Pérez-Vilaró G, Chillón M, Nogués X, et al. Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection. Nutrients. 2021;13:562
[49] Boudreault F, Pinilla-Vera M, Englert JA, Kho AT, Isabelle C, Arciniegas AJ, et al. Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight. 2017;210.1172/jci.insight.86507.
[50] Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6:25-5410.1039/c3mt00185g.
[51] Avery JC, Hoffmann PR. Selenium, Selenoproteins, and Immunity. Nutrients. 2018;10:1203
[52] Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients. 2020;12:1181
[53] Guillin OM, Vindry C, Ohlmann T, Chavatte L. Selenium, Selenoproteins and Viral Infection. Nutrients. 2019;11:2101
[54] Harthill M. Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases. Biological Trace Element Research. 2011;143:1325-3610.1007/s12011-011-8977-1.
[55] Zhang J, Taylor EW, Bennett K, Saad R, Rayman MP. Association between regional selenium status and reported outcome of COVID-19 cases in China. The American Journal of Clinical Nutrition. 2020;111:1297-910.1093/ajcn/nqaa095.
[56] Moghaddam A, Heller RA, Sun Q, Seelig J, Cherkezov A, Seibert L, et al. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients. 2020;12:2098
[57] Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118:181-910.7556/ jaoa. 2018.037.
[58] Rosanoff A, Dai Q, Shapses SA. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv Nutr. 2016;7:25-4310.3945/ an.115. 008631.
[59] Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. Journal of inflammation research. 2018;11:25
[60] Wiles ME, Wagner TL, Weglicki WB. Effect of acute magnesium deficiency (MgD) on aortic endothelial cell (EC) oxidant production. Life Sci. 1997;60:221-3610.1016/s0024-3205(96)00619-4.
[61] Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, et
al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020;17:533-510.1038/s41423-020-0402-2.
[62] Chaigne-Delalande B, Li FY, O'Connor GM, Lukacs MJ, Jiang P, Zheng L, et al. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science. 2013;341:186-9110.1126/science.1240094.
[63] Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B(12) in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020;79-80:11101710.1016/ j.nut.2020. 111017.
[64] DiNicolantonio JJ, O'Keefe JH. Magnesium and Vitamin D Deficiency as a Potential Cause of Immune Dysfunction, Cytokine Storm and Disseminated Intravascular Coagulation in covid-19 patients. Mo Med. 2021;118:68-73.